Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983277 | 0.90 | HPGD (0.63) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL14320884 | 0.82 | ALDH1A1 (0.48) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7239112 | 0.79 | HPGD (0.65) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL4009474 | 0.77 | HPGD (0.61) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL8898560 | 0.77 | POLB (0.55) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL8222746 | 0.77 | HPGD (0.61) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL735675 | 0.77 | TSHR (0.81) | HPGDTSHRALDH1A1KMT2APOLB | |
| SCHEMBL28949192 | 0.76 | HPGD (0.68) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL12424630 | 0.76 | POLB (0.74) | HPGDTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL8342174 | 0.75 | HPGD (0.63) | HPGDTSHRALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751131-A1 | MTP INHIBITING ARYL PIPERIDINES OR PIPERAZINES SUBSTITUTED WITH 5-MEMBERED HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005085226-A1 | MTP INHIBITING ARYL PIPERIDINES OR PIPERAZINES SUBSTITUTED WITH 5-MEMBERED HETEROCYCLES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-09-15 | — | — | WO | disclosed |