Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RPA1 | P27694 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1985554 | 0.91 | MAPT (0.39) | MAPTTP53GAAVDRSMN1; SMN2 | |
| SCHEMBL1986572 | 0.90 | SMN1; SMN2 (0.39) | MAPTTP53GAAVDRSMN1; SMN2 | |
| SCHEMBL1985610 | 0.88 | MAPT (0.39) | MAPTTP53SMN1; SMN2KMT2ALMNA | |
| SCHEMBL1986995 | 0.86 | KMT2A (0.35) | MAPTTP53GAASMN1; SMN2PPP1CA | |
| SCHEMBL1990290 | 0.86 | CNR2 (0.44) | LMNACNR1 | |
| SCHEMBL1986352 | 0.83 | CNR1 (0.42) | MAPTTP53GAAVDRSMN1; SMN2 | |
| SCHEMBL1983441 | 0.83 | CYP1A2 (0.45) | MAPTSMN1; SMN2PPP1CALMNARPA1 | |
| SCHEMBL1985425 | 0.83 | MALT1 (0.40) | MAPTSMN1; SMN2KMT2AMALT1LMNA | |
| SCHEMBL1983557 | 0.82 | MAPT (0.38) | MAPTTP53GAAVDRSMN1; SMN2 | |
| SCHEMBL1986855 | 0.81 | CNR1 (0.41) | MAPTTP53GAAVDRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1602656-B1 | PYRAZOLE DERIVATIVES HAVING AFFINITY FOR CB1 AND/OR CB2 RECEPTORS | NEUROSCIENZE PHARMANESS S C A R L (IT) | 2011-06-29 | — | — | EP | claimed |