Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | CASP7 | P55210 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838051 | 0.81 | PTGS1 (0.36) | ALDH1A1KDM4EMAPTHSD17B10TDP1 | |
| SCHEMBL23162632 | 0.72 | ADORA1 (0.46) | ALDH1A1KDM4EMAPTHSD17B10TDP1 | |
| SCHEMBL22528940 | 0.72 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTHSD17B10TDP1 | |
| SCHEMBL9275553 | 0.72 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTHSD17B10TDP1 | |
| SCHEMBL12332635 | 0.71 | CLK4 (0.53) | ALDH1A1HSD17B10BRCA1MAPK1USP2 | |
| SCHEMBL2749957 | 0.70 | CCNB2 (0.56) | ALDH1A1MAPTTDP1POLBMEN1 | |
| SCHEMBL5313993 | 0.70 | RAB9A (0.50) | ALDH1A1MAPTTDP1KMT2ARAB9A | |
| SCHEMBL6422496 | 0.70 | STK3 (0.61) | ALDH1A1MEN1KMT2APDPK1 | |
| SCHEMBL19716807 | 0.68 | ADORA1 (0.53) | ALDH1A1KDM4EMAPTHSD17B10TDP1 | |
| SCHEMBL1799678 | 0.68 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-08-04 | — | — | US | disclosed |
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-08-04 | — | — | US | disclosed |
| EP-3494122-B1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-09-18 | — | — | EP | disclosed |
| EP-3494122-B1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-09-18 | — | — | EP | disclosed |
| EP-3494122-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) | 2019-06-12 | — | — | EP | disclosed |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-05-16 | — | — | US | disclosed |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-05-16 | — | — | US | disclosed |
| WO-2018024265-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-02-08 | — | — | WO | disclosed |
| WO-2018024265-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | DPYD, MTAP, TYMP | ALDH1A1 2217/4885KDM4E 2292/4885MAPT 3922/4885 |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | DPYD, MTAP, TYMP | ALDH1A1 2217/4885KDM4E 2292/4885MAPT 3922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.