Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 6/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | HSPA8 | P11142 | 4/20 | 0.56 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19837990 | 0.88 | ADK (0.70) | ADKCDK5CDK5R1CDK2CDK1 | |
| SCHEMBL19837963 | 0.88 | ADK (0.69) | ADKCDK5CDK5R1CDK2CDK1 | |
| SCHEMBL19837981 | 0.86 | ADK (0.67) | ADKCDK5CDK5R1HSPA8HSPA5 | |
| SCHEMBL21351731 | 0.86 | ADK (0.67) | ADKCDK5CDK5R1CDK2CDK1 | |
| SCHEMBL21351720 | 0.86 | ADK (0.67) | ADKCDK5CDK5R1HSPA8HSPA5 | |
| SCHEMBL19837987 | 0.86 | ADK (0.67) | ADKCDK5CDK5R1CDK2CDK1 | |
| SCHEMBL19837970 | 0.86 | ADK (0.67) | ADKCDK5CDK5R1CDK2CDK1 | |
| SCHEMBL21351704 | 0.82 | ADK (0.72) | ADK | |
| SCHEMBL19837994 | 0.82 | ADK (0.72) | ADK | |
| SCHEMBL21351701 | 0.82 | ADK (1.00) | ADKCDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-08-04 | — | — | US | claimed |
| EP-3494122-B1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-09-18 | — | — | EP | claimed |
| EP-3494122-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) | 2019-06-12 | — | — | EP | claimed |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-05-16 | — | — | US | claimed |
| WO-2018024265-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-02-08 | — | — | WO | claimed |
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-08-04 | — | — | US | disclosed |
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-08-04 | — | — | US | disclosed |
| EP-3494122-B1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-09-18 | — | — | EP | disclosed |
| EP-3494122-B1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2019-09-18 | — | — | EP | disclosed |
| EP-3494122-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) | 2019-06-12 | — | — | EP | disclosed |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-05-16 | — | — | US | disclosed |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2019-05-16 | — | — | US | disclosed |
| WO-2018024265-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10730905-B2 | Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use | DPYD, MTAP, TYMP | ADK 664/4885CDK5 2752/4885CDK5R1 2998/4885 |
| US-20190144486-A1 | SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE | DPYD, MTAP, TYMP | ADK 664/4885CDK5 2752/4885CDK5R1 2998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.