Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838003 | 0.78 | TXNRD1 (0.30) | — | |
| SCHEMBL1010411 | 0.77 | PDE10A (0.39) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL17978166 | 0.77 | POLB (0.33) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL2960317 | 0.71 | POLB (0.33) | POLBTDP1NQO2 | |
| SCHEMBL31541706 | 0.70 | POLB (0.36) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL19838691 | 0.69 | POLB (0.31) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL30207735 | 0.69 | CYP1A2 (0.41) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL2969903 | 0.69 | CYP1A2 (0.41) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL1460108 | 0.67 | POLB (0.50) | POLBTDP1SIRT2SIRT1NNMT | |
| SCHEMBL29850137 | 0.67 | POLB (0.50) | POLBTDP1SIRT2SIRT1NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3494118-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | Sunshine Lake Pharma Co., Ltd. (CN) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018024224-A1 | NITROGEN-CONTAINING TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-02-08 | — | — | WO | disclosed |