Sugi Predict

Sugi Predict / Compounds / SCHEMBL1460108

SCHEMBL1460108

SCHEMBL1460108

COc1ccc(Br)c(OC)n1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ BRD9 Q9H8M2 1/20 0.38
▸ BRD7 Q9NPI1 1/20 0.38
▸ RAB9A P51151 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ PDE10A Q9Y233 2/20 0.37
▸ NQO2 P16083 3/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ SIRT2 Q8IXJ6 1/20 0.36
▸ SIRT1 Q96EB6 1/20 0.36
▸ NNMT P40261 1/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ RECQL P46063 1/20 0.36
▸ HPGD P15428 2/20 0.36
▸ TSHR P16473 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ HSD17B10 Q99714 2/20 0.36
▸ ERN1 O75460 1/20 0.36
▸ MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29850137 1.00 POLB (0.50) POLBTDP1BRD9BRD7RAB9A
SCHEMBL19715581 0.84 NQO2 (0.37) POLBTDP1NQO2CYP1A2ALDH1A1
SCHEMBL15901388 0.82 HPGD (0.37) POLBTDP1PDE10AHPGDTSHR
SCHEMBL28352970 0.79 POLB (0.45) POLBTDP1RAB9ANPC1NQO2
SCHEMBL15908315 0.79 ALDH1A1 (0.37) POLBTDP1PDE10AKMT2ACYP1A2
SCHEMBL30207735 0.79 CYP1A2 (0.41) POLBTDP1PDE10ANQO2KMT2A
SCHEMBL2969903 0.79 CYP1A2 (0.41) POLBTDP1PDE10ANQO2KMT2A
SCHEMBL20360842 0.78 BTK (0.40) POLBTDP1KMT2AHPGDTSHR
SCHEMBL1461146 0.77 NNMT (0.48) POLBTDP1BRD9BRD7RAB9A
SCHEMBL1672587 0.77 RAB9A (0.41) RAB9ANPC1NQO2HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12404253-B2 2,4,6-trisubstituted 1,3,5-triazines as modulators of CX3CR1 ASTRAZENECA AB (SE) 2025-09-02 — — US disclosed
EP-4605388-A1 <SUP2/>? <SUB2/>?3?2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CXCR1 Astrazeneca AB (SE) 2025-08-27 — — EP disclosed
CN-120077035-A As CX32,4, 6-Trisubstituted 1,3, 5-triazines as modulators of CR1 阿斯利康(瑞典)有限公司 2025-05-30 — — CN disclosed
US-20240383866-A1 2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1 ASTRAZENECA AB (SE) 2024-11-21 — — US disclosed
US-20240199558-A1 2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1 ASTRAZENECA AB (SE) 2024-06-20 — — US disclosed
WO-2024083933-A1 2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX 3CR1 ASTRAZENECA AB (SE) 2024-04-25 — — WO disclosed
US-20230203214-A1 AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-06-29 — — US disclosed
US-20230203214-A1 AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-06-29 — — US disclosed
CN-113235116-B Electrochemical synthesis method of bromopyridine derivative 齐鲁工业大学 2022-08-16 — — CN disclosed
CN-114874251-A Silicon center chiral silanol and synthetic method thereof 南方科技大学 2022-08-09 — — CN disclosed
WO-2014078778-A2 ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES BIOCRYST PHARMACEUTICALS, INC. (US) 2014-05-22 — — WO disclosed
US-20130296351-A1 2-Thiopyrimidinones PFIZER INC. 2013-11-07 — — US disclosed
WO-2013068875-A1 2-THIOPYRIMIDINONES PFIZER INC. (US) 2013-05-16 — — WO disclosed
US-20130123230-A1 2-Thiopyrimidinones PFIZER INC. 2013-05-16 — — US disclosed
EP-2480529-A1 INDOLE DERIVATIVES AS CRAC MODULATORS F. Hoffmann-La Roche AG (CH) 2012-08-01 — — EP disclosed
WO-2011036130-A1 INDOLE DERIVATIVES AS CRAC MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2011-03-31 — — WO disclosed
US-20110071150-A1 INDOLE DERIVATIVES AS CRAC MODULATORS ALAM MUZAFFAR 2011-03-24 — — US disclosed
CN-100586932-C Antitumor compound and its preparation process INST OF MEDICAL BIOTECHNOLOGY OF CHINESE ACADEMY OF MEDICAL SCIENCES 2010-02-03 — — CN disclosed
CN-101020654-A Antitumor compound and its prepn process INST OF MEDICINE BIOLOGY TECHN (CN) 2007-08-22 — — CN disclosed
US-5886182-A REDUCING PYRIDYLPHOSPHINEOXIDE COMPOUND WITH SILANE COMPOUND IN AROMATIC SOLVENT IN PRESENCE OF AN ORGANIC BASE THE HONG KONG POLYTECHNIC UNIVERSITY (HK) 1999-03-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199558-A1 2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1 CX3CR1, CCR2, CCR5 POLB 4442/4885TDP1 2513/4885BRD9 4144/4885
US-20130123230-A1 2-Thiopyrimidinones MPO, SERPINB1, TNNI3 POLB 867/4885TDP1 431/4885BRD9 1012/4885
US-20240383866-A1 2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1 CX3CR1, CCR2, CCR5 POLB 4442/4885TDP1 2513/4885BRD9 4144/4885
US-20110071150-A1 INDOLE DERIVATIVES AS CRAC MODULATORS ORAI1, RYR2, CACNA1E POLB 4868/4885TDP1 2319/4885BRD9 2582/4885
US-12404253-B2 2,4,6-trisubstituted 1,3,5-triazines as modulators of CX3CR1 CX3CR1, CCR2, CCR5 POLB 4442/4885TDP1 2513/4885BRD9 4144/4885
US-20130296351-A1 2-Thiopyrimidinones MPO, SERPINB1, TNNI3 POLB 867/4885TDP1 431/4885BRD9 1012/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.