Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 3/20 | 0.52 |
| ▸ | MC1R | Q01726 | 3/20 | 0.52 |
| ▸ | MC3R | P41968 | 2/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839742 | 1.00 | MC4R (0.52) | MC4RMC1RMC3RTGM2CTSK | |
| SCHEMBL19851733 | 0.92 | MC4R (0.53) | MC4RMC1RMC3RTGM2CTSK | |
| SCHEMBL19839673 | 0.88 | MEN1 (0.55) | CTSKCA1CA2MAPTMEN1 | |
| SCHEMBL19839675 | 0.88 | MEN1 (0.55) | CTSKCA1CA2MAPTMEN1 | |
| SCHEMBL19839686 | 0.88 | MEN1 (0.55) | CTSKCA1CA2MAPTMEN1 | |
| SCHEMBL19839791 | 0.87 | CA1 (0.52) | CTSKCTSSCA1CA2MAPT | |
| SCHEMBL19839794 | 0.87 | CA1 (0.52) | CTSKCTSSCA1CA2MAPT | |
| SCHEMBL19851498 | 0.85 | MC4R (0.51) | MC4RMC1RMC3RCTSKCTSB | |
| SCHEMBL7647888 | 0.82 | CTSS (0.62) | CTSKCTSBCTSSCA2ACE | |
| SCHEMBL7954332 | 0.82 | CTSS (0.62) | CTSKCTSBCTSSCA2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493814-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | Neuropore Therapies, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| CN-109715167-A | Lipid-substituted amino 1, 2-and 1, 3-diol compounds as modulators of TLR2 dimerization | 神经孔疗法股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | disclosed |