Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833613 | 0.70 | BACE1 (0.49) | BACE1 | |
| SCHEMBL11307514 | 0.62 | MEN1 (0.43) | OPRM1OPRL1MEN1KMT2AALDH1A1 | |
| SCHEMBL10155295 | 0.62 | BACE1 (0.54) | BACE1TAAR1 | |
| SCHEMBL8700016 | 0.62 | CYP1A2 (0.66) | CHRNA7CYP2A6 | |
| Phenethylamine SCHEMBL28297992 | 0.60 | CHRNA7 (0.67) | CYP3A4CHRNA7TAAR1CYP2A6MAOA | |
| SCHEMBL8200325 | 0.59 | CYP2A6 (0.68) | CHRNA7CYP2A6 | |
| SCHEMBL8199794 | 0.59 | TDP1 (0.71) | CHRNA7CYP2A6 | |
| SCHEMBL12040598 | 0.58 | HRH1 (0.72) | CHRNA7CYP2A6 | |
| SCHEMBL13098626 | 0.58 | HRH1 (0.72) | CHRNA7CYP2A6 | |
| SCHEMBL9792691 | 0.58 | ALDH1A1 (0.39) | CYP3A4OPRM1OPRL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3493803-A1 | GP130 MODULATORS | The Regents of The University of California (US) | 2019-06-12 | — | — | EP | disclosed |
| WO-2018027193-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-08 | — | — | WO | disclosed |