Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330236 | 0.82 | BACE1 (0.70) | BACE1KCNH2 | |
| SCHEMBL5052720 | 0.72 | BACE1 (0.65) | BACE1KCNH2 | |
| SCHEMBL10154760 | 0.71 | BACE1 (0.49) | BACE1KCNH2 | |
| SCHEMBL19839752 | 0.70 | BACE1 (0.36) | BACE1 | |
| SCHEMBL159063 | 0.69 | HCAR2 (0.38) | BACE1 | |
| SCHEMBL4134312 | 0.69 | BACE1 (0.71) | BACE1BACE2 | |
| SCHEMBL17033073 | 0.66 | ALDH1A1 (0.41) | — | |
| SCHEMBL16052004 | 0.66 | BACE1 (0.51) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL10154712 | 0.66 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL13306647 | 0.66 | BACE1 (1.00) | BACE1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234011-B1 | 4-(1,2,5,6-TETRAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES AND 4-(HEXAHYDRO-1-ALKYL-3-PYRIDINYL)-2-THIAZOLAMINES | WARNER-LAMBERT COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |