Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.73 |
| ▸ | AKT1 | P31749 | 2/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984590 | 1.00 | ROCK2 (0.73) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL12561730 | 0.89 | RPS6KB1 (0.74) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL12561687 | 0.89 | RPS6KB1 (0.74) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL1985525 | 0.86 | ROCK2 (0.69) | ROCK2AKT1RPS6KB1ROCK1 | |
| SCHEMBL1990142 | 0.86 | RPS6KB1 (0.71) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL1984020 | 0.85 | ROCK2 (0.72) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL1989572 | 0.85 | RPS6KB1 (0.72) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL1252326 | 0.84 | ROCK2 (1.00) | ROCK2RPS6KB1 | |
| SCHEMBL1988483 | 0.84 | ROCK2 (1.00) | ROCK2AKT1RPS6KB1ROCK1TSHR | |
| SCHEMBL1988490 | 0.84 | ROCK2 (1.00) | ROCK2AKT1RPS6KB1ROCK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, RHOT2 | ROCK2 4/4885AKT1 31/4885RPS6KB1 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.