Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19833873 | 0.90 | MAP3K5 (0.43) | MAP3K5TP53PKMMAPK1NR3C2 | |
| SCHEMBL19848105 | 0.86 | MAP3K5 (0.37) | MAP3K5TP53NR3C2NR3C1TRPV1 | |
| SCHEMBL19847887 | 0.82 | NR3C2 (0.40) | MAP3K5NR3C2NR3C1TRPV1DHODH | |
| SCHEMBL19833759 | 0.81 | MAP3K5 (0.42) | MAP3K5TP53NR3C2NR3C1TRPV1 | |
| SCHEMBL19848056 | 0.79 | NR3C2 (0.44) | MAP3K5NR3C2NR3C1PGRKCNH2 | |
| SCHEMBL19847964 | 0.78 | MGLL (0.44) | TP53PKMTRPV1LMNAMAPT | |
| SCHEMBL19833835 | 0.78 | CPS1 (0.41) | MAP3K5NR3C2NR3C1TRPV1DHODH | |
| SCHEMBL19847992 | 0.77 | MGLL (0.53) | TP53NR3C2NR3C1LMNAMAPT | |
| SCHEMBL19833912 | 0.76 | NR3C2 (0.39) | MAP3K5TP53NR3C2NR3C1TRPV1 | |
| SCHEMBL19848040 | 0.76 | MGLL (0.45) | TP53PKMLMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3279191-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-02 | — | — | EP | disclosed |
| EP-3279191-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-07 | — | — | EP | disclosed |