Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1118464 | 0.87 | GPR119 (0.51) | GPR119 | |
| SCHEMBL19850477 | 0.84 | GPR119 (0.54) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| SCHEMBL19850532 | 0.83 | GPR119 (0.49) | GPR119THRBF2RL3MAPTKDM4E | |
| SCHEMBL3144261 | 0.79 | GPR119 (0.60) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| SCHEMBL1269808 | 0.78 | GPR119 (0.51) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| SCHEMBL12897372 | 0.78 | GPR119 (0.54) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| SCHEMBL27975342 | 0.78 | GPR119 (0.54) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| Iodide SCHEMBL1270227 | 0.77 | GPR119 (0.55) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| SCHEMBL2732435 | 0.77 | GPR119 (0.55) | GPR119SMN1; SMN2THRBGAAF2RL3 | |
| SCHEMBL907209 | 0.77 | GPR119 (0.58) | GPR119SMN1; SMN2THRBGAAF2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026890-A1 | OXYMETHYLENE ARYL COMPOUNDS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES OR GASTROINTESTINAL CONDITIONS | CYMABAY THERAPEUTICS (US) | 2018-02-08 | — | — | WO | disclosed |