Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.69 |
| ▸ | CTRC | Q99895 | 1/20 | 0.69 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.58 |
| ▸ | CCR4 | P51679 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19839869 | 0.86 | RAB9A (0.70) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL23742583 | 0.85 | CCR4 (0.67) | MEN1KMT2ASMN1; SMN2MAPTRECQL | |
| SCHEMBL19851003 | 0.83 | CTRB1 (0.64) | MEN1KMT2AMAPTCTRB1CTRC | |
| SCHEMBL23742652 | 0.83 | NPY5R (0.69) | MEN1KMT2ASMN1; SMN2MAPTCTRB1 | |
| SCHEMBL23742582 | 0.82 | CYP1A1 (0.57) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL1820221 | 0.80 | NPY5R (0.88) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL7113430 | 0.80 | NPY5R (0.57) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL23742626 | 0.79 | CYP1A1 (0.88) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL28712020 | 0.77 | CYP1A1 (0.68) | MEN1KMT2ACTRB1CTRCCYP1A1 | |
| SCHEMBL1891977 | 0.77 | ROCK1 (0.68) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947207-B2 | GP130 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947207-B2 | GP130 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190292161-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-09-26 | — | — | US | disclosed |
| US-20190292161-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-09-26 | — | — | US | disclosed |
| WO-2018027193-A1 | GP130 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292161-A1 | GP130 MODULATORS | GRIN2A, GRIA4, GRIA3 | MEN1 4541/4885KMT2A 3926/4885SMN1; SMN2 758/4885 |
| US-10947207-B2 | GP130 modulators | GRIN2A, GRIA4, GRIA3 | MEN1 4541/4885KMT2A 3926/4885SMN1; SMN2 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.