Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 11/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | FGR | P09769 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 2/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19650815 | 0.80 | OPRL1 (0.34) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL24816292 | 0.79 | KDM4E (0.36) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL19844859 | 0.79 | KDM4E (0.40) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL3433903 | 0.77 | MPO (0.43) | MPONPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18055557 | 0.77 | KDM4E (0.38) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL6887721 | 0.77 | MAP3K12 (0.40) | KDM4EKMT2ARET | |
| SCHEMBL24117763 | 0.76 | ALDH1A1 (0.40) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL21178704 | 0.75 | KDM4E (0.38) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL15283440 | 0.75 | NPC1 (0.41) | KDM4EKMT2ARETCYP1A2HCK | |
| SCHEMBL19091627 | 0.75 | KDM4E (0.40) | KDM4EKMT2ARETCYP1A2HCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633386-B2 | BET protein degraders | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190169195-A1 | BET PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2019-06-06 | — | — | US | disclosed |
| US-10307407-B2 | 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180036294-A1 | 9H-PYRIMIDO [4,5-B] INDOLES AS BET BROMODOMAIN INHIBITORS | UNIV MICHIGAN REGENTS (US) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10307407-B2 | 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors | BRD4, BRD3, BRD1 | KDM4E 390/4885KMT2A 180/4885RET 2119/4885 |
| US-20180036294-A1 | 9H-PYRIMIDO [4,5-B] INDOLES AS BET BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | KDM4E 390/4885KMT2A 180/4885RET 2119/4885 |
| US-10633386-B2 | BET protein degraders | BRD4, BET1, BRD1 | KDM4E 110/4885KMT2A 279/4885RET 2865/4885 |
| US-20190169195-A1 | BET PROTEIN DEGRADERS | BRD4, BET1, BRD1 | KDM4E 122/4885KMT2A 315/4885RET 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.