Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19837309 | 0.79 | MBOAT4 (0.39) | MBOAT4KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL19837448 | 0.79 | KDM4E (0.39) | MBOAT4KDM4EALDH1A1CNR2 | |
| SCHEMBL18017351 | 0.75 | UHRF1 (0.45) | CHRNA7KDM4ECNR2CHRM4CNR1 | |
| SCHEMBL19837312 | 0.75 | MBOAT4 (0.37) | MBOAT4KDM4EALDH1A1 | |
| SCHEMBL21927208 | 0.74 | UHRF1 (0.38) | MBOAT4KDM4EALDH1A1AR | |
| SCHEMBL2751008 | 0.72 | UHRF1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL19225568 | 0.72 | CHRNA7 (0.39) | CHRNA7CNR2KCNH2CHRM4CNR1 | |
| SCHEMBL25930436 | 0.72 | UHRF1 (0.47) | MBOAT4CHRNA7CNR2CNR1CYP17A1 | |
| SCHEMBL24278226 | 0.71 | XDH (0.46) | CNR2AR | |
| SCHEMBL21212290 | 0.71 | UHRF1 (0.40) | CHRNA7KDM4ECNR2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3494120-B1 | OXADIAZOLOPYRIDINE DERIVATIVES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-17 | — | — | EP | disclosed |
| WO-2018024653-A1 | OXADIAZOLOPYRIDINE DERIVATES FOR USE AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-08 | — | — | WO | disclosed |