Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 7/20 | 0.72 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851664 | 1.00 | TLR2 (0.72) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL19851861 | 0.94 | TLR2 (0.69) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL19839673 | 0.89 | MEN1 (0.55) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL19839686 | 0.89 | MEN1 (0.55) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL19839675 | 0.89 | MEN1 (0.55) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL19851534 | 0.89 | TLR2 (0.57) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL28292694 | 0.87 | TLR2 (0.55) | TLR2CTSKCA1CA2MEN1 | |
| SCHEMBL19851705 | 0.87 | TLR2 (0.74) | TLR2CTSKCA1CA2 | |
| SCHEMBL19851520 | 0.87 | TLR2 (0.74) | TLR2CTSKCA1CA2 | |
| SCHEMBL19851496 | 0.87 | TLR2 (0.74) | TLR2CTSKCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715167-A | Lipid-substituted amino 1, 2-and 1, 3-diol compounds as modulators of TLR2 dimerization | 神经孔疗法股份有限公司 | 2019-05-03 | — | — | CN | claimed |
| CN-109715167-A | Lipid-substituted amino 1, 2-and 1, 3-diol compounds as modulators of TLR2 dimerization | 神经孔疗法股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| WO-2018026866-A1 | LIPID-SUBSTITUTED AMINO 1,2-AND 1,3-DIOL COMPOUNDS AS MODULATORS OF TLR2 DIMERIZATION | NEUROPORE THERAPIES, INC. (US) | 2018-02-08 | — | — | WO | disclosed |