Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2040432 | 0.81 | NLRP3 (0.47) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL2090679 | 0.79 | NLRP3 (0.79) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL9532866 | 0.77 | NLRP3 (0.51) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL1275026 | 0.76 | CYP1A2 (0.54) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL1275580 | 0.75 | NLRP3 (0.44) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL34472907 | 0.75 | L3MBTL1 (0.43) | KDM4ERAB9AHPGDMEN1KMT2A | |
| SCHEMBL1984373 | 0.74 | NLRP3 (0.46) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL8782314 | 0.74 | CA12 (0.53) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL7558526 | 0.73 | NLRP3 (0.54) | NLRP3KDM4EGLAPOLBSMN1; SMN2 | |
| SCHEMBL8251624 | 0.72 | SMN1; SMN2 (0.58) | KDM4EPOLBSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079103-A1 | SPIROPIPERIDINE BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |