Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | CHKA | P35790 | 7/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894415 | 0.86 | LMNA (0.68) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL20710201 | 0.84 | HRH3 (0.64) | NCF1ALDH1A1HRH3KDM4ESMN1; SMN2 | |
| SCHEMBL21378560 | 0.83 | LMNA (0.64) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL19778598 | 0.83 | LMNA (0.64) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL15960142 | 0.83 | LMNA (0.64) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL18737247 | 0.81 | HRH3 (0.61) | LMNAALDH1A1HRH3HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21273658 | 0.81 | LMNA (0.62) | LMNAMC4RCHKACA2NCF1 | |
| Hydrochloric Acid SCHEMBL21273655 | 0.81 | LMNA (0.62) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL26378176 | 0.81 | CHKA (0.68) | LMNAMC4RCHKACA2NCF1 | |
| SCHEMBL12017826 | 0.81 | LMNA (0.57) | LMNAMC4RCHKACA2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | LMNA 2477/4885MC4R 1266/4885CHKA 1244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.