Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20214878 | 0.90 | CYP1A2 (0.40) | CYP1A2CYP2C19NOS1DRD2SLC6A4 | |
| SCHEMBL18559460 | 0.86 | CYP1A2 (0.44) | CYP1A2CYP2C19NOS1DRD2SLC6A4 | |
| SCHEMBL18556889 | 0.80 | KDM4C (0.38) | KDM4E | |
| SCHEMBL6842156 | 0.78 | CYP1A2 (0.50) | CYP1A2CYP2C19NOS1DRD2SLC6A4 | |
| SCHEMBL20676148 | 0.77 | NOS1 (0.50) | CYP1A2CYP2C19NOS1DRD2SLC6A4 | |
| SCHEMBL27580013 | 0.74 | CYP1A2 (0.37) | CYP1A2CYP2C19NOS1DRD2SLC6A4 | |
| SCHEMBL19308820 | 0.70 | KDM4E (0.43) | CYP1A2CYP2C19KDM4EALDH1A1GAA | |
| SCHEMBL29303865 | 0.68 | FFAR1 (0.33) | FFAR1GPR84ELANEMPO | |
| SCHEMBL19853487 | 0.67 | CYP1A2 (0.50) | CYP1A2CYP2C19NOS1DRD2SLC6A4 | |
| SCHEMBL21362866 | 0.67 | SMN1; SMN2 (0.43) | CYP1A2CYP2C19ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352343-B2 | Urea derivatives and uses thereof | KALA PHARMACEUTICALS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200299272-A1 | Urea Derivatives and Uses Thereof | KALA BIO, Inc. | 2020-09-24 | — | — | US | disclosed |
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | KALA BIO, Inc. | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352343-B2 | Urea derivatives and uses thereof | UACA, RB1, FLT1 | CYP1A2 3517/4885CYP2C19 1538/4885NOS1 43/4885 |
| US-20180037573-A1 | UREA DERIVATIVES AND USES THEREOF | UACA, RB1, FLT1 | CYP1A2 3517/4885CYP2C19 1538/4885NOS1 43/4885 |
| US-20200299272-A1 | Urea Derivatives and Uses Thereof | UACA, RB1, FLT1 | CYP1A2 3517/4885CYP2C19 1538/4885NOS1 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.