Sugi Predict

Sugi Predict / Compounds / SCHEMBL19852656

SCHEMBL19852656

SCHEMBL19852656

C=C[C@H](O)[C@@H](Cc1ccc(F)cc1)C(C)OCc1ccc(OC)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 2/20 0.40
▸ SLC6A4 P31645 1/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ PPARG P37231 1/20 0.38
▸ PPARA Q07869 1/20 0.38
▸ ATM Q13315 1/20 0.37
▸ LDHA P00338 1/20 0.37
▸ MAOB P27338 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ TP53 P04637 1/20 0.36
▸ CYP3A4 P08684 1/20 0.36
▸ ALOX15 P16050 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ ALOX12 P18054 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17417060 1.00 FFAR1 (0.40) FFAR1SLC6A4KMT2AMEN1KDM4E
SCHEMBL28610510 1.00 FFAR1 (0.40) FFAR1SLC6A4KMT2AMEN1KDM4E
SCHEMBL17892914 1.00 FFAR1 (0.40) FFAR1SLC6A4KMT2AMEN1KDM4E
SCHEMBL19852736 0.89 RCE1 (0.45) FFAR1SLC6A4KMT2AMEN1L3MBTL1
SCHEMBL16859407 0.89 RCE1 (0.45) FFAR1SLC6A4KMT2AMEN1L3MBTL1
SCHEMBL16863572 0.89 RCE1 (0.45) FFAR1SLC6A4KMT2AMEN1L3MBTL1
SCHEMBL19852683 0.89 RCE1 (0.45) FFAR1SLC6A4KMT2AMEN1L3MBTL1
SCHEMBL19739505 0.89 RCE1 (0.45) FFAR1SLC6A4KMT2AMEN1L3MBTL1
SCHEMBL16859422 0.89 RCE1 (0.45) FFAR1SLC6A4KMT2AMEN1L3MBTL1
SCHEMBL16859402 0.81 FFAR1 (0.39) FFAR1SLC6A4POLBMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3240408-B1 PICOLINAMIDES WITH FUNGICIDAL ACTIVITY DOW AGROSCIENCES LLC (US) 2020-04-08 — — EP disclosed
US-20190359557-A1 PICOLINAMIDES WITH FUNGICIDAL ACTIVITY DOW AGROSCIENCES LLC (US) 2019-11-28 — — US disclosed
US-10252989-B2 Picolinamides with fungicidal activity DOW AGROSCIENCES LLC (US) 2019-04-09 — — US disclosed
US-10173971-B2 Picolinamides with fungicidal activity DOW AGROSCIENCES LLC (US) 2019-01-08 — — US disclosed
US-20180037541-A1 PICOLINAMIDES WITH FUNGICIDAL ACTIVITY CORTEVA AGRISCIENCE LLC 2018-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180037541-A1 PICOLINAMIDES WITH FUNGICIDAL ACTIVITY CYP51A1, CYP1A2, FKBP14 FFAR1 1151/4885SLC6A4 3213/4885KMT2A 3486/4885
US-20190359557-A1 PICOLINAMIDES WITH FUNGICIDAL ACTIVITY CYP51A1, CYP1A2, FKBP14 FFAR1 1151/4885SLC6A4 3213/4885KMT2A 3486/4885
US-10173971-B2 Picolinamides with fungicidal activity CYP51A1, CYP1A2, FKBP14 FFAR1 1151/4885SLC6A4 3213/4885KMT2A 3486/4885
US-10252989-B2 Picolinamides with fungicidal activity CYP51A1, CYP1A2, FKBP14 FFAR1 1151/4885SLC6A4 3213/4885KMT2A 3486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.