FKBP14

Peptidyl-prolyl cis-trans isomerase FKBP14 · Q9NWM8 · FKBP14 on Sugi Atlas →

104 patent compounds predicted against FKBP14, 97 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cycloheximide (SCHEMBL26617)	1.00	1/20
Cycloheximide (SCHEMBL674135)	1.00	1/20
Cycloheximide (SCHEMBL1714687)	1.00	1/20
Cycloheximide (SCHEMBL1753509)	1.00	1/20
Cycloheximide (SCHEMBL3764335)	1.00	1/20
Cycloheximide (SCHEMBL3764340)	1.00	1/20
Cycloheximide (SCHEMBL9344504)	1.00	1/20
Cycloheximide (SCHEMBL17223570)	1.00	1/20
Cycloheximide (SCHEMBL24914327)	1.00	1/20
Naramycin B (SCHEMBL29356383)	1.00	1/20
Cycloheximide (SCHEMBL30020292)	1.00	1/20
Cycloheximide (SCHEMBL7376217)	0.97	1/20
Cycloheximide (SCHEMBL7459729)	0.97	1/20
Cycloheximide (SCHEMBL23320333)	0.97	1/20
Cycloheximide (SCHEMBL20972370)	0.92	1/20
Cycloheximide (SCHEMBL28231243)	0.92	1/20
Cycloheximide (SCHEMBL8095473)	0.90	1/20
Cycloheximide (SCHEMBL27991761)	0.88	1/20
Cycloheximide (SCHEMBL14685897)	0.83	1/20
SCHEMBL12207307	0.83	1/20

Clinical trials — most relevant to FKBP14 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris	PHASE4	UNKNOWN
Tacrolimus Treatment for Refractory Autoimmune Cytopenia	PHASE4	UNKNOWN
CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing	PHASE4	COMPLETED
Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL)	PHASE2	COMPLETED
Cyclosporine For The Treatment Of COVID-19(+)	PHASE2	COMPLETED
FK506 (Tacrolimus) in Pulmonary Arterial Hypertension	PHASE2	COMPLETED
Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer	PHASE2	COMPLETED
IL-2 for Multi Drug Resistant Nephrotic Syndrome	PHASE1/PHASE2	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Neurosteroids for PTSD in Veterans	PHASE2	COMPLETED
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors	PHASE1	WITHDRAWN
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects	PHASE1	COMPLETED
Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants	PHASE1	COMPLETED
FKBP5 Methylation and Childhood Emotional Abuse in Complex Posttraumatic Stress Disorder: Investigating the Relationship and Its Predictive Role in Therapy Outcome	nan	COMPLETED
Clinical Implications of FKBP5 in Stroke	nan	UNKNOWN
Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer	nan	WITHDRAWN
Quantification of GADD34 Expression in RA	nan	COMPLETED
Cortisol, Hippocampus, and Insula in Anorexia Nervosa.	nan	RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Multi-level Molecular Profiling of High Acute Stress: a Clinical Study	nan	UNKNOWN
Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Genetic Predictors of Lithium Response in Bipolar Disorder	nan	COMPLETED
Gene Polymorphisms in Tacrolimus Drug Interactions	nan	COMPLETED
Biomarkers in Idiopathic Juvenile Arthritis	nan	UNKNOWN
Evaluation of Interaction Between Immunosuppressive Drugs and Protein-bound Uremic Toxins in Renal Transplant Patients	nan	WITHDRAWN
Establishment of Human Cellular Disease Models for Wilson Disease	nan	COMPLETED
Cyclosporin A Therapy in Childhood Nephrotic Syndrome	nan	UNKNOWN
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FKBP14 binder may also engage these)

Protein	Name	Similarity
Q5R941	—	1.000	Q5R941 →
P59024	—	1.000	P59024 →
Q9Y680	—	0.993	Q9Y680 →
Q5RET2	—	0.988	Q5RET2 →
O54998	—	0.987	O54998 →
Q32PA9	—	0.981	Q32PA9 →
P0CP97	—	0.978	P0CP97 →
P45878	—	0.978	P45878 →
Q38936	—	0.974	Q38936 →
Q38935	—	0.973	Q38935 →
Q61576	—	0.972	Q61576 →
Q6CGG3	—	0.972	Q6CGG3 →
Q41649	—	0.972	Q41649 →
Q6BP84	—	0.972	Q6BP84 →
P0CP96	—	0.972	P0CP96 →
Q96AY3	—	0.970	Q96AY3 →
P81628	—	0.969	P81628 →
Q2KIL5	—	0.968	Q2KIL5 →
Q2HJ89	—	0.968	Q2HJ89 →
Q96EU7	—	0.968	Q96EU7 →
O77633	—	0.967	O77633 →
Q54SR7	—	0.967	Q54SR7 →
Q9C8J4	—	0.967	Q9C8J4 →
Q9D1M7	—	0.967	Q9D1M7 →
Q5U2T9	—	0.967	Q5U2T9 →
Q921X9	—	0.967	Q921X9 →
Q6FSC1	—	0.967	Q6FSC1 →
Q6CUZ8	—	0.966	Q6CUZ8 →
Q98931	—	0.966	Q98931 →
Q91687	—	0.966	Q91687 →