Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.71 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737450 | 0.84 | IDO1 (1.00) | IDO1ALDH1A1HTTSCN9ASCN5A | |
| SCHEMBL3772396 | 0.76 | PTGES2 (1.00) | PTGES2ALDH1A1HTTRECQLEIF2AK3 | |
| SCHEMBL17737767 | 0.74 | IDO1 (0.67) | IDO1ALDH1A1RECQLDDX3XKMT2A | |
| SCHEMBL10239556 | 0.74 | PTGES2 (0.62) | PTGES2ALDH1A1HTTRECQLEIF2AK3 | |
| SCHEMBL3534196 | 0.73 | PTGES2 (0.58) | PTGES2ALDH1A1HTTRECQLEIF2AK3 | |
| SCHEMBL17737675 | 0.73 | IDO1 (0.63) | IDO1PTGES2ALDH1A1HTTRECQL | |
| Hydrochloric Acid SCHEMBL9958373 | 0.73 | PTGES2 (0.61) | PTGES2ALDH1A1HTTRECQLEIF2AK3 | |
| SCHEMBL17737441 | 0.73 | IDO1 (0.62) | IDO1ALDH1A1HTTRECQLDDX3X | |
| SCHEMBL19852954 | 0.73 | IDO1 (0.62) | IDO1ALDH1A1HTTRECQLDDX3X | |
| SCHEMBL22536976 | 0.73 | CYP11B1 (0.50) | IDO1PTGES2ALDH1A1HTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215155-B1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2020-10-14 | — | — | EP | disclosed |
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | IDO1 3/4885PTGES2 1534/4885ALDH1A1 3640/4885 |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | TDO2, IDO2, IDO1 | IDO1 3/4885PTGES2 1534/4885ALDH1A1 3640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.