Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.60 |
| ▸ | CKS1B | P61024 | 2/20 | 0.60 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.60 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737441 | 0.89 | IDO1 (0.62) | IDO1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL19852956 | 0.87 | RECQL (0.69) | IDO1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL17737675 | 0.87 | IDO1 (0.63) | IDO1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL15452718 | 0.86 | IDO1 (0.62) | IDO1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL17737362 | 0.86 | IDO1 (0.62) | IDO1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1040890 | 0.86 | GLO1 (0.62) | IDO1ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL17737442 | 0.86 | GLO1 (0.62) | IDO1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL17737766 | 0.85 | IDO1 (0.61) | IDO1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL27214264 | 0.83 | SLC40A1 (0.66) | IDO1KMT2AALDH1A1MAPTTDP1 | |
| SCHEMBL19853016 | 0.83 | TDP1 (0.65) | IDO1KMT2AMAPTTDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | IDO1 3/4885KMT2A 1561/4885ALDH1A1 3640/4885 |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | TDO2, IDO2, IDO1 | IDO1 3/4885KMT2A 1561/4885ALDH1A1 3640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.