Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.57 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.57 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.57 |
| ▸ | G6PD | P11413 | 1/20 | 0.57 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | METAP1 | P53582 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | DDX3X | O00571 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737766 | 0.92 | IDO1 (0.61) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17737617 | 0.88 | RECQL (0.69) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17737362 | 0.87 | IDO1 (0.62) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17737441 | 0.87 | IDO1 (0.62) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL19852954 | 0.87 | IDO1 (0.62) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL15452718 | 0.87 | IDO1 (0.62) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17737767 | 0.86 | IDO1 (0.67) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL17737365 | 0.85 | IDO1 (0.63) | RECQLIDO1KMT2AALDH1A1MAPT | |
| SCHEMBL17737675 | 0.85 | IDO1 (0.63) | RECQLIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL12220834 | 0.85 | KCNA5 (0.52) | RECQLIDO1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215155-B1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2020-10-14 | — | — | EP | disclosed |
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | RECQL 1366/4885IDO1 3/4885KMT2A 1561/4885 |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | TDO2, IDO2, IDO1 | RECQL 1366/4885IDO1 3/4885KMT2A 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.