Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28012865 | 0.83 | LMNA (0.31) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL28012864 | 0.83 | LMNA (0.31) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL27632708 | 0.83 | LMNA (0.31) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL27891101 | 0.82 | MMP8 (0.35) | MMP8GRM2GRM3LMNATSHR | |
| SCHEMBL609954 | 0.81 | MMP8 (0.37) | MMP8GRM2GRM3CYP2C19TDP1 | |
| SCHEMBL27721862 | 0.81 | LMNA (0.34) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL27403747 | 0.81 | LMNA (0.33) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL27717113 | 0.81 | LMNA (0.34) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL28132589 | 0.81 | LMNA (0.33) | LMNATSHRCYP2C9CHRM2CHRM4 | |
| SCHEMBL28132590 | 0.81 | LMNA (0.33) | LMNATSHRCYP2C9CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1976921-A | Crystalline forms of (3R) -1- (2-methylalanyl-D-tryptophyl) -3- (phenylmethyl) -3-piperidinecarboxylic acid 1,2, 2-trimethylhydrazide | SAPPHIRE THERAPEUTICS INC (US) | 2007-06-06 | — | — | CN | claimed |
| CN-116096714-A | Antiviral compounds for the treatment of coronavirus, picornavirus and norovirus infections | 安力高医药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| WO-2021134004-A1 | CYCLIC COMPOUNDS AND METHODS OF USING SAME | SCHRODINGER, INC. (US) | 2021-07-01 | — | — | WO | disclosed |
| CN-108368084-B | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-10-16 | — | — | CN | disclosed |
| EP-3278786-B1 | DENTAL MATERIALS ON THE BASIS OF VINYLCYCLOPROPANE DERIVATIVES CONTAINING URETHANE GROUPS | IVOCLAR VIVADENT AG (LI) | 2019-01-23 | — | — | EP | disclosed |
| WO-2018024706-A1 | DENTAL MATERIALS BASED ON VINYLCYCLOPROPANE DERIVATIVES CONTAINING URETHANE GROUPS | IVOCLAR VIVADENT AG (LI) | 2018-02-08 | — | — | WO | disclosed |
| CN-1976921-B | Crystalline forms of (3R) -1- (2-methylalanyl-D-tryptophyl) -3- (phenylmethyl) -3-piperidinecarboxylic acid 1,2, 2-trimethylhydrazide | SAPPHIRE THERAPEUTICS INC | 2013-08-21 | — | — | CN | disclosed |
| CN-103025716-A | Bicyclic compound derivatives and their use as acc inhibitors | TAKEDA PHARMACEUTICAL | 2013-04-03 | — | — | CN | disclosed |
| CN-102584937-A | Crystal forms of (3r)-1-(2-methylalanyl-d-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide | HELSINN THERAPEUTICS US INC | 2012-07-18 | — | — | CN | disclosed |
| CN-101679397-A | Quinolone and tetrahydroquinoline having NOS inhibitory activity and related compounds | NEURAXON INC | 2010-03-24 | — | — | CN | disclosed |
| CN-101605798-A | Imidazothiazole derivative | DAIICHI SANKYO CO LTD (JP) | 2009-12-16 | — | — | CN | disclosed |
| CN-101466712-A | Thioxanthine derivatives and their use as inhibitors of mpo | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |
| CN-1976921-A | Crystalline forms of (3R) -1- (2-methylalanyl-D-tryptophyl) -3- (phenylmethyl) -3-piperidinecarboxylic acid 1,2, 2-trimethylhydrazide | SAPPHIRE THERAPEUTICS INC (US) | 2007-06-06 | — | — | CN | disclosed |
| CN-1198818-C | compounds with growth hormone releasing properties | NOVO NORDISK AS (DK) | 2005-04-27 | — | — | CN | disclosed |
| CN-1530107-A | Insulin resistance treatment by growth hormone secretory hormone | �Ʒ� | 2004-09-22 | — | — | CN | disclosed |
| CN-1152049-C | Treatment of insulin resistance with growth hormone secretagogues | �Ʒ� | 2004-06-02 | — | — | CN | disclosed |
| CN-1420878-A | compounds with growth hormone releasing properties | NOVO NORDISK AS (DK) | 2003-05-28 | — | — | CN | disclosed |