SCHEMBL1985362

SCHEMBL1985362

Cl[Ti](Cl)c1cccc2c1Cc1ccccc1-2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.49
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
HTR7 P34969 1/20 0.40
HTR2B P41595 1/20 0.40
MAOA P21397 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ACHE P22303 3/20 0.36
BCHE P06276 2/20 0.36
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8160722 0.81 PNMT (0.49) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL30103334 0.79 PNMT (0.63) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL524602 0.79 PNMT (0.63) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL27885618 0.77 PNMT (0.57) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL2877998 0.77 PNMT (0.61) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL8154235 0.77 PNMT (0.45) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL4080810 0.77 NPC1 (0.50) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL22263591 0.74 PNMT (0.57) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL7930811 0.74 PNMT (0.53) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL30485506 0.74 PNMT (0.53) PNMTNPC1RAB9AHTR7HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4384556-A1 PROCESS FOR PRODUCING POLYOLEFIN GRANULAR RESIN WITH INCREASED SETTLED BULK DENSITY W. R. Grace & Co.-Conn (US) 2024-06-19 EP disclosed
WO-2023178116-A1 SILICA-SUPPORTED POLYOLEFIN CATALYST SYSTEM W. R. GRACE & CO.-CONN (US) 2023-09-21 WO disclosed
WO-2023177433-A1 PROCESS FOR PRODUCING HEAT TREATED SUPPORTED ALUMINOXANES IN AN ALIPHATIC SOLVENT USING SOLID ALUMINOXANES W.R. GRACE & CO.-CONN. (US) 2023-09-21 WO disclosed
EP-4223802-A2 POLYMERIZATION CATALYST Univation Technologies, LLC (US) 2023-08-09 EP disclosed
EP-2953985-B1 PREPARATION OF POLYOLEFIN UNIVATION TECH LLC (US) 2023-06-07 EP disclosed
WO-2023069328-A1 PROCESS FOR PRODUCING A SINGLE SITE CATALYST W.R. GRACE & CO.-CONN. (US) 2023-04-27 WO disclosed
WO-2023018671-A1 PROCESS FOR PRODUCING POLYOLEFIN GRANULAR RESIN WITH INCREASED SETTLED BULK DENSITY W.R. GRACE & CO.-CONN. (US) 2023-02-16 WO disclosed
EP-3998292-A1 PRODUCING POLYETHYLENE PRODUCTS WITH IMPROVED STIFFNESS, TOUGHNESS, AND PROCESSABILITY Univation Technologies, LLC (US) 2022-05-18 EP disclosed
EP-3998293-A1 PRODUCING POLYETHYLENE PRODUCTS WITH IMPROVED STIFFNESS, TOUGHNESS, AND PROCESSABILITY Univation Technologies, LLC (US) 2022-05-18 EP disclosed
EP-2938434-B1 SUPPORTED CATALYST WITH IMPROVED FLOWABILITY UNIVATION TECH LLC (US) 2022-05-04 EP disclosed
WO-1997042165-A1 FLUORENE SUBSTITUTED WITH A GROUP COMPRISING A HETERO ATOM DSM N.V. (NL) 1997-11-13 WO disclosed
US-5674795-A SLURRYING WITH A COCATALYST ACTIVATOR UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-10-07 US disclosed
EP-0784062-A2 Process for production of long-chain branched polyolefins UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-07-16 EP disclosed
EP-0770629-A2 A process for preparing an in situ polyethylene blend UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1997-05-02 EP disclosed
WO-1996040796-A1 HALOGENATED SUPPORTS AND SUPPORTED ACTIVATORS W.R. GRACE & CO.-CONN. (US) 1996-12-19 WO disclosed
WO-1996013531-A1 PREPARATION OF MODIFIED POLYOLEFIN CATALYSTS AND IN SITU PREPARATION OF SUPPORTED METALLOCENE AND ZIEGLER-NATTA/METALLOCENE POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 1996-05-09 WO disclosed
EP-0593083-B1 Gas phase polymerization reaction utilizing soluble unsupported catalysts UNION CARBIDE CHEM PLASTIC (US) 1996-05-01 EP disclosed
US-5434115-A Process for producing olefin polymer TOSOH CORPORATION (JP) 1995-07-18 US disclosed
US-5317036-A Continuous catalytic vapor phase polymerization of olefins UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-05-31 US disclosed
EP-0593083-A1 Gas phase polymerization reaction utilizing soluble unsupported catalysts UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1994-04-20 EP disclosed