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SCHEMBL19853626

SCHEMBL19853626

Cn1cc2cc([S+]([O-])NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CC6(CCC6)CC5)CC4)cc3Oc3cnc4[nH]ccc4c3)cc([N+](=O)[O-])c2n1

nearest known ligand 0.69

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19853766 0.93 BCL2 (0.70) BCL2
SCHEMBL21573186 0.92 BCL2 (0.70) BCL2
SCHEMBL23865993 0.92 BCL2 (0.75) BCL2
SCHEMBL22562897 0.92 BCL2 (0.69) BCL2
SCHEMBL19839927 0.90 BCL2 (0.84) BCL2
SCHEMBL29373716 0.90 BCL2 (0.84) BCL2
SCHEMBL19853741 0.90 BCL2 (0.82) BCL2
SCHEMBL19853635 0.90 BCL2 (0.72) BCL2
SCHEMBL21573218 0.90 BCL2 (0.71) BCL2
SCHEMBL21573183 0.90 BCL2 (0.69) BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3672594-B1 COMBINATION PRODUCT OF BCL-2 INHIBITOR AND MDM2 INHIBITOR AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2021-09-29 — — EP disclosed
EP-3672595-B1 COMBINATION PRODUCT OF BCL-2 INHIBITOR AND CHEMOTHERAPEUTIC AGENT AND USE THEREOF IN THE PREVENTION AND/OR TREATMENT OF DISEASES ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2021-07-21 — — EP disclosed
WO-2018027097-A1 N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2018-02-08 — — WO disclosed
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