Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1985565 | 0.79 | MAPT (0.43) | BCHEACHEKDM4EALDH1A1LMNA | |
| SCHEMBL903733 | 0.73 | WEE1 (0.40) | WEE1BCHEACHEALOX5PTGS1 | |
| SCHEMBL1984996 | 0.71 | — | — | |
| SCHEMBL11808516 | 0.66 | BCHE (0.67) | WEE1BCHEACHEALOX5PTGS1 | |
| SCHEMBL15497482 | 0.65 | KDM4E (0.43) | KDM4E | |
| SCHEMBL1987572 | 0.64 | — | — | |
| SCHEMBL1989124 | 0.64 | — | — | |
| SCHEMBL22023550 | 0.64 | ESR1 (0.68) | BCHEACHEALOX5PTGS1PTGS2 | |
| SCHEMBL1985699 | 0.64 | — | — | |
| SCHEMBL6955129 | 0.64 | CYP2C19 (0.36) | WEE1KDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303037-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-05 | — | — | US | disclosed |
| US-9303037-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-05 | — | — | US | disclosed |
| US-9303037-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-05 | — | — | US | disclosed |
| US-20140066479-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-20140066479-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-06 | — | — | US | disclosed |
| US-20140066479-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-06 | — | — | US | disclosed |
| EP-1796664-B1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2013-11-27 | — | — | EP | disclosed |
| US-8580840-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-11-12 | — | — | US | disclosed |
| US-8580840-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-11-12 | — | — | US | disclosed |
| US-8580840-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-11-12 | — | — | US | disclosed |
| US-7696239-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-13 | — | — | US | disclosed |
| US-7696239-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-13 | — | — | US | disclosed |
| US-20080114048-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | SUI ZHIHUA | 2008-05-15 | — | — | US | disclosed |
| US-20080114048-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | SUI ZHIHUA | 2008-05-15 | — | — | US | disclosed |
| US-20080114048-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | SUI ZHIHUA | 2008-05-15 | — | — | US | disclosed |
| US-7338973-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-04 | — | — | US | disclosed |
| US-7338973-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-04 | — | — | US | disclosed |
| US-7338973-B2 | Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-04 | — | — | US | disclosed |
| US-20060116415-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| US-20060116513-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116415-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | NR5A1, ESRRA, SHBG | WEE1 3409/4885BCHE 4176/4885ACHE 4847/4885 |
| US-20060116513-A1 | Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators | NR5A1, ESRRA, SHBG | WEE1 3409/4885BCHE 4176/4885ACHE 4847/4885 |
| US-20140066479-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | NR5A1, ESRRA, SHBG | WEE1 3409/4885BCHE 4176/4885ACHE 4847/4885 |
| US-20080114048-A1 | NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS | NR5A1, ESRRA, SHBG | WEE1 3409/4885BCHE 4176/4885ACHE 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.