Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21034807 | 0.87 | LMNA (0.36) | LMNABLM | |
| SCHEMBL19839352 | 0.74 | PARP1 (0.31) | — | |
| SCHEMBL24634211 | 0.74 | PARP1 (0.31) | — | |
| SCHEMBL19839351 | 0.74 | PARP1 (0.31) | — | |
| SCHEMBL19853734 | 0.74 | MTNR1A (0.36) | LMNABLM | |
| SCHEMBL21034808 | 0.68 | LMNA (0.42) | LMNABLMITGA4 | |
| SCHEMBL24634215 | 0.67 | — | — | |
| SCHEMBL23153056 | 0.66 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL19853677 | 0.65 | SMYD3 (0.41) | LMNA | |
| SCHEMBL24178999 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018026763-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC. (US) | 2018-02-08 | — | — | WO | disclosed |