Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 2/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 4/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.36 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.36 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1550050 | 1.00 | CYP51A1 (0.40) | CYP51A1DRD2HTR2BSTAT6HTRA1 | |
| SCHEMBL1549976 | 1.00 | CYP51A1 (0.40) | CYP51A1DRD2HTR2BSTAT6HTRA1 | |
| SCHEMBL1550049 | 0.95 | DRD2 (0.37) | CYP51A1DRD2HTR2BSTAT6HTRA1 | |
| SCHEMBL12552765 | 0.95 | DRD2 (0.37) | CYP51A1DRD2STAT6HTRA1KDM5A | |
| SCHEMBL1550086 | 0.94 | HTRA1 (0.38) | CYP51A1DRD2HTR2BSTAT6HTRA1 | |
| SCHEMBL1550758 | 0.94 | NAMPT (0.40) | CYP51A1DRD2STAT6HTRA1KDM5A | |
| SCHEMBL1550068 | 0.93 | STAT6 (0.39) | CYP51A1DRD2STAT6HTRA1PYGL | |
| SCHEMBL7934666 | 0.93 | DRD2 (0.40) | DRD2HTRA1 | |
| SCHEMBL1930930 | 0.93 | VHL (0.37) | CYP51A1DRD2STAT6HTRA1KDM5A | |
| SCHEMBL1550222 | 0.93 | VHL (0.37) | CYP51A1DRD2STAT6HTRA1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |