Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.40 |
| ▸ | DRD3 | P35462 | 16/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12552765 | 0.94 | DRD2 (0.37) | DRD2DRD3OPRM1DRD4DRD1 | |
| SCHEMBL19856859 | 0.93 | CYP51A1 (0.40) | DRD2HTRA1 | |
| SCHEMBL1550050 | 0.93 | CYP51A1 (0.40) | DRD2HTRA1 | |
| SCHEMBL1549976 | 0.93 | CYP51A1 (0.40) | DRD2HTRA1 | |
| SCHEMBL7942793 | 0.91 | SCN3A (0.37) | DRD2DRD3OPRM1DRD4DRD1 | |
| SCHEMBL7933956 | 0.91 | SCN3A (0.37) | DRD2DRD3OPRM1DRD4DRD1 | |
| SCHEMBL1550758 | 0.90 | NAMPT (0.40) | DRD2DRD3HTRA1 | |
| SCHEMBL1550086 | 0.90 | HTRA1 (0.38) | DRD2SCN4ASCN3AHTRA1 | |
| SCHEMBL1550049 | 0.90 | DRD2 (0.37) | DRD2SCN4ASCN3AHTRA1 | |
| SCHEMBL16456898 | 0.90 | DRD2 (0.38) | DRD2SCN4ASCN3AHTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |