Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856950 | 1.00 | NPC1 (0.47) | NPC1RAB9ASTAT6CTSLCTSS | |
| SCHEMBL19856861 | 0.93 | STAT6 (0.45) | NPC1RAB9ASTAT6DRD2FLT3 | |
| SCHEMBL19856863 | 0.93 | STAT6 (0.45) | NPC1RAB9ASTAT6DRD2FLT3 | |
| SCHEMBL19856894 | 0.91 | DRD2 (0.45) | NPC1RAB9ASTAT6DRD2TAS1R3 | |
| SCHEMBL19856892 | 0.91 | DRD2 (0.45) | NPC1RAB9ASTAT6DRD2TAS1R3 | |
| SCHEMBL1550637 | 0.91 | PDGFRB (0.48) | NPC1RAB9ASTAT6PDGFRBPDGFRA | |
| SCHEMBL1549612 | 0.91 | PDGFRB (0.48) | NPC1RAB9ASTAT6CTSLCTSS | |
| SCHEMBL19856870 | 0.91 | DRD2 (0.43) | STAT6PDGFRBPDGFRADRD2TAS1R3 | |
| SCHEMBL19856869 | 0.91 | DRD2 (0.43) | STAT6PDGFRBPDGFRADRD2TAS1R3 | |
| SCHEMBL19856879 | 0.91 | DRD2 (0.43) | STAT6DRD2DRD3TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |