Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 2/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 7/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23619076 | 0.93 | PDE2A (0.34) | TACR3KIF18AGCKPDE2ACNR2 | |
| SCHEMBL23619077 | 0.87 | MAPK1 (0.41) | KIF18AGCKPDE2AMAPK1CBLB | |
| SCHEMBL19864475 | 0.82 | TACR3 (0.34) | TACR3PDE2ACNR2 | |
| SCHEMBL19859210 | 0.82 | MAPK8 (0.42) | MAPK1 | |
| SCHEMBL23619030 | 0.80 | RORC (0.41) | PDE2AMAPK1 | |
| SCHEMBL19864427 | 0.80 | MAPK1 (0.38) | GCKPDE2AMAPK1 | |
| SCHEMBL19859421 | 0.79 | KIF18A (0.35) | KIF18ACNR2 | |
| SCHEMBL19864490 | 0.75 | PDE2A (0.37) | PDE2AMAPK1 | |
| SCHEMBL19864656 | 0.75 | MAPK1 (0.39) | PDE2AMAPK1 | |
| SCHEMBL19864669 | 0.74 | MAPK8 (0.43) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018030550-A1 | HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-02-15 | — | — | WO | disclosed |