Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.37 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.35 |
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805267 | 0.89 | MAP4K1 (0.48) | MAP4K1TNIKMAP3K9MAP3K11CLK1 | |
| SCHEMBL19860029 | 0.84 | SIK1 (0.35) | MAP4K1CLK1DYRK1AALKSIK1 | |
| SCHEMBL15805272 | 0.76 | MAP4K1 (0.49) | MAP4K1TNIKMAP3K9MAP3K11MAPK1 | |
| SCHEMBL15805271 | 0.73 | SIK1 (0.47) | MAP4K1MAP3K11ALKSIK1SIK3 | |
| SCHEMBL17636825 | 0.70 | SIK1 (0.50) | MAP4K1MAP3K11SIK1SIK3MAPK1 | |
| SCHEMBL15799169 | 0.65 | SIK1 (0.75) | MAP4K1TNIKMAP3K11ALKSIK1 | |
| SCHEMBL19860027 | 0.65 | SIK1 (0.65) | TNIKALKSIK1SIK3PDPK1 | |
| SCHEMBL21676921 | 0.65 | MAPK1 (0.39) | MAP4K1TNIKMAP3K11MAPK1 | |
| SCHEMBL15556786 | 0.64 | ALK (0.68) | MAP4K1TNIKMAP3K9MAP3K11ALK | |
| SCHEMBL19860025 | 0.63 | SIK1 (0.46) | MAP4K1TNIKMAP3K11ALKSIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890153-B2 | Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-02-13 | — | — | US | disclosed |