Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805271 | 0.89 | SIK1 (0.47) | SIK1SIK3JAK2PIK3CDROCK2 | |
| SCHEMBL19860030 | 0.84 | MAP4K1 (0.44) | SIK1SIK3CLK1DYRK1AMAPK1 | |
| SCHEMBL17636825 | 0.78 | SIK1 (0.50) | SIK1SIK3JAK2PIK3CDROCK2 | |
| SCHEMBL15805269 | 0.76 | MAPK1 (0.40) | JAK2TDO2MAPK1MAP4K1 | |
| SCHEMBL19860023 | 0.75 | SIK1 (0.60) | SIK1SIK3PIK3CDPIK3CAALK | |
| SCHEMBL15805267 | 0.73 | MAP4K1 (0.48) | SIK1SIK3CLK1DYRK1ACDK9 | |
| SCHEMBL19860025 | 0.71 | SIK1 (0.46) | SIK1SIK3ALKMAP4K1 | |
| SCHEMBL19860026 | 0.67 | SIK1 (0.59) | SIK1SIK3PIK3CDPIK3CAALK | |
| SCHEMBL15799340 | 0.65 | SIK1 (0.77) | SIK1SIK3CCNT1CDK9ALK | |
| SCHEMBL30830390 | 0.65 | SIK1 (0.77) | SIK1SIK3CCNT1CDK9ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890153-B2 | Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-02-13 | — | — | US | disclosed |