Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983646 | 0.92 | HRH3 (0.48) | HRH4HRH3GHSR | |
| SCHEMBL2013817 | 0.83 | HRH3 (0.50) | HRH4HRH3MAP4K4 | |
| SCHEMBL4392709 | 0.80 | HRH4 (0.66) | HRH4HRH3 | |
| SCHEMBL603250 | 0.79 | HRH4 (0.78) | HRH4HRH3 | |
| SCHEMBL6023054 | 0.79 | HTR3A (0.54) | HRH4MAP4K4 | |
| SCHEMBL5076739 | 0.76 | LMNA (0.56) | HRH4HRH3MAP4K4 | |
| SCHEMBL6023882 | 0.76 | LMNA (0.56) | HRH4HRH3MAP4K4 | |
| SCHEMBL1775506 | 0.76 | LMNA (0.56) | HRH4HRH3MAP4K4 | |
| SCHEMBL3205164 | 0.76 | HRH4 (0.51) | HRH4HRH3NAPEPLD | |
| SCHEMBL14574680 | 0.75 | HRH3 (0.56) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516420-B1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | MEDICIS PHARMACEUTICAL CORP (US) | 2018-08-22 | — | — | EP | disclosed |
| EP-2516420-A1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | Palau Pharma, S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076878-A1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | PALAU PHARMA, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |