Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.82 |
| ▸ | IGF1R | P08069 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19860192 | 0.92 | EGFR (0.80) | EGFRIGF1RKCNH2 | |
| SCHEMBL19239592 | 0.90 | EGFR (0.82) | EGFRIGF1RKCNH2 | |
| SCHEMBL17467217 | 0.90 | EGFR (1.00) | EGFRIGF1RKCNH2 | |
| SCHEMBL19860193 | 0.88 | EGFR (0.73) | EGFRIGF1RKCNH2 | |
| SCHEMBL19860188 | 0.87 | EGFR (0.76) | EGFRIGF1RKCNH2 | |
| SCHEMBL20574578 | 0.86 | EGFR (0.63) | EGFRIGF1RKCNH2 | |
| SCHEMBL19860190 | 0.86 | EGFR (0.73) | EGFRIGF1RKCNH2JAK3 | |
| SCHEMBL19860187 | 0.85 | EGFR (0.72) | EGFRIGF1RKCNH2JAK3 | |
| SCHEMBL19860792 | 0.84 | EGFR (0.70) | EGFRIGF1RKCNH2JAK3 | |
| SCHEMBL18921733 | 0.84 | EGFR (0.61) | EGFRIGF1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890168-B2 | 2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2018-02-13 | — | — | US | disclosed |
| US-9890168-B2 | 2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidine derivative, preparation method and medicinal use thereof | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2018-02-13 | — | — | US | disclosed |