Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGFRL1 | Q5TC84 | 10/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22225553 | 0.91 | OGFRL1 (0.51) | OGFRL1OPRM1OPRK1OPRD1MAPK1 | |
| SCHEMBL21366177 | 0.85 | OGFRL1 (0.49) | OGFRL1OPRM1OPRK1OPRD1MAPK1 | |
| SCHEMBL20206668 | 0.83 | ALDH1A1 (0.53) | OGFRL1OPRM1OPRK1OPRD1MAPK1 | |
| SCHEMBL16382145 | 0.79 | OGFRL1 (0.59) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL21366175 | 0.78 | OGFRL1 (0.46) | OGFRL1OPRM1OPRK1OPRD1MAPK1 | |
| SCHEMBL21548044 | 0.76 | OGFRL1 (0.49) | OGFRL1OPRM1OPRK1OPRD1NR1H4 | |
| SCHEMBL21548047 | 0.76 | OGFRL1 (0.49) | OGFRL1OPRM1OPRK1OPRD1NR1H4 | |
| SCHEMBL16731186 | 0.75 | OGFRL1 (0.46) | OGFRL1OPRM1OPRK1OPRD1MAPK1 | |
| SCHEMBL10285467 | 0.74 | OGFRL1 (0.50) | OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL21547994 | 0.74 | OGFRL1 (0.52) | OGFRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890164-B2 | Substituted-quinoxaline-type bridged-piperidine compounds as ORL-1 modulators | PURDUE PHARMA, L.P. (US) | 2018-02-13 | — | — | US | disclosed |