Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986126 | 1.00 | KMT2A (0.46) | KMT2ACFTRCTSKMAPTBAZ2B | |
| SCHEMBL1990437 | 0.89 | BAZ2B (0.49) | CFTRCTSKMAPTBAZ2BLMNA | |
| SCHEMBL1990436 | 0.89 | BAZ2B (0.49) | CFTRCTSKMAPTBAZ2BLMNA | |
| SCHEMBL1988307 | 0.89 | LMNA (0.48) | KMT2ACFTRCTSKMAPTBAZ2B | |
| SCHEMBL1988306 | 0.89 | LMNA (0.48) | KMT2ACFTRCTSKMAPTBAZ2B | |
| SCHEMBL1992066 | 0.82 | CHRNA7 (0.44) | CFTRKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL1992069 | 0.82 | CHRNA7 (0.44) | CFTRKDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL1987945 | 0.74 | TAAR1 (0.47) | KMT2AKDM4ETAAR1 | |
| SCHEMBL1987946 | 0.74 | TAAR1 (0.47) | KMT2AKDM4ETAAR1 | |
| SCHEMBL1989217 | 0.72 | PADI4 (0.33) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809532-B2 | Aza-ring fused indole and indoline derivatives | ABBVIE INC. (US) | 2014-08-19 | — | — | US | claimed |
| US-20110152308-A1 | AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | claimed |
| US-8809532-B2 | Aza-ring fused indole and indoline derivatives | ABBVIE INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20110152308-A1 | AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152308-A1 | AZA-RING FUSED INDOLE AND INDOLINE DERIVATIVES | INMT, IDO1, IDO2 | KMT2A 84/4885CFTR 2902/4885CTSK 3860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.