Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19861650 | 0.78 | USP2 (0.41) | CHRNB2CHRNB4CHRNA4HTR2A | |
| SCHEMBL2736121 | 0.77 | PIK3CD (0.34) | PIK3CD | |
| SCHEMBL18532047 | 0.75 | PIK3CD (0.33) | PIK3CD | |
| SCHEMBL16625968 | 0.74 | PIK3CD (0.45) | LSSCYP2D6CYP2C19PIK3CDHTR2A | |
| SCHEMBL26272105 | 0.70 | LSS (0.34) | LSS | |
| SCHEMBL19233450 | 0.69 | ACE2 (0.44) | — | |
| SCHEMBL16625956 | 0.69 | PIK3CD (0.44) | LSSCYP2D6CYP2C19PIK3CD | |
| SCHEMBL13744639 | 0.68 | LSS (0.35) | LSS | |
| SCHEMBL2736112 | 0.68 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA4 | |
| SCHEMBL17406690 | 0.67 | LMNA (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9891239-B2 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2018-02-13 | — | — | US | disclosed |