Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
| ▸ | PDE6D | O43924 | 2/20 | 0.43 |
| ▸ | PDE6A | P16499 | 2/20 | 0.43 |
| ▸ | PDE6G | P18545 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE6B | P35913 | 2/20 | 0.43 |
| ▸ | PDE6C | P51160 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27250162 | 0.80 | MIF (0.43) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL17103079 | 0.80 | GRM2 (0.54) | GRM2KEAP1PDE2APDE6DPDE6A | |
| SCHEMBL27250062 | 0.77 | MIF (0.41) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL256210 | 0.75 | SLC9A1 (0.50) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL30036706 | 0.75 | SLC9A1 (0.50) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL10734042 | 0.73 | SLC9A1 (0.48) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL19911637 | 0.73 | GRM2 (0.62) | GRM2KEAP1SLC9A1 | |
| SCHEMBL31474375 | 0.73 | SLC9A1 (0.48) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL19911638 | 0.73 | GRM2 (0.50) | GRM2KEAP1SLC9A1NPC1RAB9A | |
| SCHEMBL1965207 | 0.73 | SLC9A1 (0.48) | GRM2KEAP1SLC9A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890166-B2 | Imidazopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2018-02-13 | — | — | US | disclosed |