Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.75 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.52 |
| ▸ | TUBB | P07437 | 5/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 8/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863384 | 1.00 | SRC (0.75) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863389 | 0.91 | SRC (0.65) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863393 | 0.91 | TUBB4A (0.63) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863407 | 0.90 | SRC (0.63) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863396 | 0.90 | SRC (0.60) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863390 | 0.90 | SRC (0.60) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863394 | 0.87 | SRC (0.57) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19863395 | 0.87 | SRC (0.57) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| Kx2-361 SCHEMBL254057 | 0.86 | SRC (1.00) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| Kx2-361 SCHEMBL29385376 | 0.86 | SRC (1.00) | SRCTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | ATHENEX, INC. | 2021-07-01 | — | — | US | disclosed |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | ATHENEX, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2019-05-02 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | SRC 81/4885TUBB4A 1008/4885TUBB 779/4885 |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | SRC 81/4885TUBB4A 1008/4885TUBB 779/4885 |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | PLK1, MAP3K2, TNK2 | SRC 81/4885TUBB4A 1008/4885TUBB 779/4885 |
| US-20210196724-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | SRC 81/4885TUBB4A 1008/4885TUBB 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.