Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 17/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19863419 | 1.00 | PIK3C3 (0.48) | PIK3C3ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL22652053 | 0.85 | PIK3C3 (0.48) | PIK3C3 | |
| SCHEMBL16611301 | 0.80 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL19863417 | 0.80 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL25222723 | 0.80 | PIK3C3 (0.49) | PIK3C3 | |
| SCHEMBL23866041 | 0.79 | PIK3C3 (0.48) | PIK3C3 | |
| SCHEMBL21256945 | 0.78 | PIK3C3 (0.50) | PIK3C3 | |
| SCHEMBL26515061 | 0.78 | PIK3C3 (0.50) | PIK3C3 | |
| SCHEMBL2599609 | 0.78 | PIK3C3 (0.48) | PIK3C3 | |
| SCHEMBL2599611 | 0.78 | PIK3C3 (0.48) | PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | ATHENEX, INC. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2019-05-02 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042934-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885ALDH1A1 3493/4885LMNA 1201/4885 |
| US-20190125754-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885ALDH1A1 3493/4885LMNA 1201/4885 |
| US-10973828-B2 | Biaryl compositions and methods for modulating a kinase cascade | PLK1, MAP3K2, TNK2 | PIK3C3 616/4885ALDH1A1 3493/4885LMNA 1201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.