Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.79 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.70 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.70 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.70 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.70 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.70 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.70 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.70 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.70 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.70 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.62 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10074118 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL11063589 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL21710850 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL24897216 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL23483076 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL24404377 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL24437428 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL23483146 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL22626977 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA | |
| SCHEMBL22627010 | 0.88 | GPBAR1 (1.00) | GPBAR1NR1H4MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002339-A1 | FLUORINATED AND ALKYLATED BILE ACIDS | METSELEX, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11072630-B2 | Fluorinated and alkylated bile acids | METSELEX, INC. (US) | 2021-07-27 | — | — | US | disclosed |
| US-20180044373-A1 | FLUORINATED AND ALKYLATED BILE ACIDS | METSELEX, INC. | 2018-02-15 | — | — | US | disclosed |
| US-20180044373-A1 | FLUORINATED AND ALKYLATED BILE ACIDS | METSELEX, INC. | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072630-B2 | Fluorinated and alkylated bile acids | NR1H4, SLC10A1, SLC10A2 | GPBAR1 4/4885NR1H4 1/4885MEN1 1571/4885 |
| US-20220002339-A1 | FLUORINATED AND ALKYLATED BILE ACIDS | NR1H4, SLC10A1, SLC10A2 | GPBAR1 4/4885NR1H4 1/4885MEN1 1571/4885 |
| US-20180044373-A1 | FLUORINATED AND ALKYLATED BILE ACIDS | NR1H4, SLC10A1, SLC10A2 | GPBAR1 4/4885NR1H4 1/4885MEN1 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.