Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | F2R | P25116 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014491 | 0.90 | ALDH1A1 (0.67) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL19864779 | 0.90 | ALDH1A1 (0.67) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL13018 | 0.87 | ALDH1A1 (0.63) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL12449650 | 0.87 | ALDH1A1 (0.63) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL15314570 | 0.83 | NAMPT (0.49) | LMNAKMT2AITGB3ITGA2BF2R | |
| SCHEMBL12251 | 0.83 | ALDH1A1 (0.58) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL12256 | 0.83 | ALDH1A1 (0.58) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL25499137 | 0.83 | ITGB3 (0.52) | ALDH1A1LMNAMEN1KMT2AITGB3 | |
| SCHEMBL25513436 | 0.82 | ITGB3 (0.43) | ALDH1A1LMNAMEN1KMT2APOLB | |
| SCHEMBL12593581 | 0.82 | NAMPT (0.47) | ALDH1A1LMNAMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198031-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | Merck Patent GmbH (DE) | 2023-06-21 | — | — | EP | disclosed |
| EP-3497094-B1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2023-02-15 | — | — | EP | disclosed |
| WO-2018031434-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-02-15 | — | — | WO | disclosed |