Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 9/20 | 0.33 |
| ▸ | VEGFA | P15692 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865196 | 0.82 | CCR2 (0.33) | EPAS1 | |
| SCHEMBL19865454 | 0.79 | EPAS1 (0.44) | EPAS1VEGFA | |
| SCHEMBL19865197 | 0.77 | CA1 (0.36) | — | |
| SCHEMBL19865338 | 0.75 | EPAS1 (0.33) | EPAS1VEGFA | |
| SCHEMBL19865314 | 0.73 | EPAS1 (0.51) | EPAS1VEGFA | |
| SCHEMBL19865251 | 0.72 | PDE2A (0.31) | — | |
| SCHEMBL19865460 | 0.69 | — | — | |
| SCHEMBL19865457 | 0.68 | VEGFA (0.33) | EPAS1VEGFA | |
| SCHEMBL19865302 | 0.67 | — | — | |
| SCHEMBL16555606 | 0.65 | EPAS1 (0.38) | EPAS1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031680-A1 | NOVEL COMPOUNDS, USES AND METHODS FOR THEIR PREPARATION | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2018-02-15 | — | — | WO | disclosed |