Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 5/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21090587 | 0.84 | LPL (0.35) | LPLLIPGF11 | |
| SCHEMBL19865577 | 0.81 | LPL (0.31) | LPLLIPG | |
| SCHEMBL4977958 | 0.81 | LPL (0.40) | LPLLIPG | |
| SCHEMBL21090923 | 0.80 | LPL (0.32) | LPLLIPG | |
| SCHEMBL24845746 | 0.76 | LPL (0.44) | LPLLIPGF11ESR2NPSR1 | |
| SCHEMBL22084681 | 0.72 | CDC7 (0.35) | — | |
| SCHEMBL22084689 | 0.71 | HPGD (0.36) | — | |
| SCHEMBL11300523 | 0.71 | LPL (0.72) | LPLLIPGF11ESR2HIF1A | |
| SCHEMBL22084424 | 0.71 | PDE10A (0.38) | — | |
| SCHEMBL19865291 | 0.67 | LPL (0.43) | LPLLIPGF11ESR2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031662-A1 | PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF | GENENTECH, INC. (US) | 2018-02-15 | — | — | WO | disclosed |