Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 20/20 | 0.65 |
| ▸ | VEGFA | P15692 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ARNT | P27540 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865445 | 0.90 | EPAS1 (0.49) | EPAS1VEGFA | |
| SCHEMBL19865176 | 0.88 | EPAS1 (0.59) | EPAS1VEGFA | |
| SCHEMBL19865265 | 0.88 | EPAS1 (0.60) | EPAS1VEGFA | |
| SCHEMBL16555681 | 0.83 | EPAS1 (0.69) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865424 | 0.82 | VEGFA (0.52) | EPAS1VEGFA | |
| SCHEMBL19865245 | 0.82 | VEGFA (0.54) | EPAS1VEGFACYP2C9 | |
| SCHEMBL16555329 | 0.80 | EPAS1 (0.82) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL16555711 | 0.79 | EPAS1 (0.81) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL17671253 | 0.79 | EPAS1 (0.68) | EPAS1VEGFACYP2C9ARNTCYP2C19 | |
| SCHEMBL19865407 | 0.78 | EPAS1 (0.72) | EPAS1VEGFACYP2C9ARNTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031680-A1 | NOVEL COMPOUNDS, USES AND METHODS FOR THEIR PREPARATION | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2018-02-15 | — | — | WO | disclosed |