Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 16/20 | 0.49 |
| ▸ | VEGFA | P15692 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865425 | 0.90 | EPAS1 (0.65) | EPAS1VEGFA | |
| SCHEMBL19865466 | 0.86 | EPAS1 (0.52) | EPAS1VEGFA | |
| SCHEMBL19865314 | 0.82 | EPAS1 (0.51) | EPAS1VEGFA | |
| SCHEMBL19865213 | 0.78 | VEGFA (0.45) | EPAS1VEGFA | |
| SCHEMBL19865176 | 0.77 | EPAS1 (0.59) | EPAS1VEGFA | |
| SCHEMBL19865265 | 0.77 | EPAS1 (0.60) | EPAS1VEGFA | |
| SCHEMBL19865196 | 0.76 | CCR2 (0.33) | EPAS1PTGS2 | |
| SCHEMBL18036866 | 0.76 | EPAS1 (0.67) | EPAS1VEGFA | |
| SCHEMBL19865405 | 0.74 | VEGFA (0.63) | EPAS1VEGFA | |
| SCHEMBL19865406 | 0.74 | VEGFA (0.63) | EPAS1VEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018031680-A1 | NOVEL COMPOUNDS, USES AND METHODS FOR THEIR PREPARATION | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2018-02-15 | — | — | WO | disclosed |