Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 10/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 10/20 | 0.47 |
| ▸ | BMX | P51813 | 10/20 | 0.47 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23648843 | 0.87 | TNK2 (0.44) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL30018529 | 0.87 | TNK2 (0.44) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL23648389 | 0.85 | TNK2 (0.45) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL19922636 | 0.84 | TNK2 (0.42) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL4472920 | 0.81 | FGFR1 (0.46) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL23045888 | 0.81 | TNK2 (0.47) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL19865443 | 0.79 | TNK2 (0.72) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL30340763 | 0.77 | FGFR4 (0.40) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL3580202 | 0.76 | FGFR4 (0.39) | TNK2MAP4K2BMXABL1LCK | |
| SCHEMBL31264954 | 0.76 | FGFR4 (0.42) | FGFR1FGFR3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530221-B2 | Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-12-20 | — | — | US | disclosed |
| US-20210061810-A1 | PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2021-03-04 | — | — | US | disclosed |
| US-10155767-B2 | Therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-D]pyrimidine-2(1H)-one derivatives | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-12-18 | — | — | US | disclosed |
| US-10059717-B2 | Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-08-28 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065969-A1 | THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-03-08 | — | — | US | disclosed |
| WO-2018030800-A1 | UREA COMPOUND HAVING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE SKELETON HAVING PROTEIN KINASE INHIBITING ACTIVITY | 한국과학기술연구원 | 2018-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11530221-B2 | Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors | LCK, CDK2, CDK5 | TNK2 53/4885MAP4K2 82/4885BMX 1092/4885 |
| US-10155767-B2 | Therapeutic agent of acute myeloid leukemia containing 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-D]pyrimidine-2(1H)-one derivatives | GAK, DCK, NRAS | TNK2 38/4885MAP4K2 50/4885BMX 592/4885 |
| US-20180065969-A1 | THERAPEUTIC AGENT OF ACUTE MYELOID LEUKEMIA CONTAINING 1,3,7-TRISUBSTITUTED 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDINE-2(1H)-ONE DERIVATIVES | GAK, DCK, NRAS | TNK2 38/4885MAP4K2 50/4885BMX 592/4885 |
| US-20210061810-A1 | PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | LCK, CDK2, CDK5 | TNK2 86/4885MAP4K2 90/4885BMX 1010/4885 |
| US-10059717-B2 | Urea compounds containing 3,4-dihydropyrimido[4,5-D]pyrimidin-2(1H)-one skeleton as protein kinase inhibitors | MAP4K2, CMPK1, MTOR | TNK2 230/4885MAP4K2 1/4885BMX 1107/4885 |
| US-20180065970-A1 | UREA COMPOUNDS CONTAINING 3,4-DIHYDROPYRIMIDO[4,5-D]PYRIMIDIN-2(1H)-ONE SKELETON AS PROTEIN KINASE INHIBITORS | MAP4K2, CMPK1, MTOR | TNK2 230/4885MAP4K2 1/4885BMX 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.